Endocrine Abstracts

Aims: Condition that influence erythrocyte turnover also affect HbA1c. Although many forms of anemia are associated with lowering of HbA1c, iron-deficiency anemia (IDA) tends to increase HbA1c. In this study, we examined the relationship between HbA1c and erythrocyte indices in non-diabetic pregnancy and assessed the effect of iron supplementation on HbA1c.Methods: 150 women were studied (30 non-diabetic, non-pregnant, non-anemic women in child bearing w...

Medicago sativa plants are commonly used as green fodder. In this study, estrogen-like activity of ethanolic extract of Medicago sativa plants and its possible effects on serum biochemical metabolites in immature female rats were investigated. Crude extract of dried Medicago sativa plants was prepared in 90% ethanol using Soxhlet’s apparatus. Fifteen immature female rats were divided into 3 equal groups. Rats of groups A and B were given the extract at the dose of 250 (lo...

Background and aims: Proper assessment of long-term safety of newer antidiabetic agents (ADAs) is of prime importance as diabetes is a chronic disease requiring life-long management. The purpose of this analysis was to assess the safety of vildagliptin as monotherapy or as an add-on therapy to already existing ADAs (vildagliptin group) compared to non-vildagliptin group.Materials and methods: Nine hundred and eighty-three patients in vildagliptin group a...

Objectives: To investigate effects of testosterone in hypogonadal men with Crohn’s disease (CD).Design and methods: Thirteen men, aged 45–67 years were diagnosed with subnormal plasma testosterone. They received treatment with parenteral testosterone undecanoate. They also suffered from CD. The Crohn’s disease activity index (CDAI) (1) was used to assess the severity of the disease. Levels of testosterone and C-reactive protein (CRP) were ...

Introduction: Endocrinopathies can cause secondary osteoporosis and little is known of the extent of this condition in young adults.Methods: In order to assess the bone health in endocrinopathies in young adults, a retrospective analysis of 25 transitional clinic patients who underwent dual energy X-ray absorptiometry (DEXA scan) was made using case notes and the hospital database.Results: Twenty-three patients were male and the me...

Radioactive iodine (RAI) has been in use for more than 60 years with satisfactory results RAI and safe profile, there has been a different outcome of treatment in different ethnic groups. We assessed the demographic features and clinical outcome of a Jordanian and British cohorts of patients treated with RAI.Methods: Hyperthyroid patients who opted RAI as a primary therapy and those who had relapse after treatment with antithyroid drugs (ATD) or h...

Aims: Determine the utility of ultrasonography for the preoperative localization of enlarged parathyroid glands in primary hyperparathyroidism and to compare this method with 99mtechnetium sestamibi scintigraphy.Methods: The results of ultrasonographic localization of enlarged parathyroid glands witch were performed by one experienced ultrasonographer were determined in 65 consecutive patients with primary hyperparathyroidism and compared with...

Objective: To investigate the associations between adiponectin levels and adiposity and body fat distribution indices assessed by waist to hip ratio in Iranian women and to determine if the association differ as a result of ethnicity.Methods: A cross-sectional study of 76 Iranian women free from metabolic disease was performed. Body mass index (BMI), waist circumferences, waist to hip ratio (WHR), body composition, insulin sensitivity, lipid profiles and...

Introduction: Cobalt is a relatively rare magnetic element with properties similar to iron and nickel. Cobalt is an essential element necessary for the formation of vitamin B12; however, excessive administration of this trace element produces goiter and reduced thyroid activity. This study was done to compare the prevalence of cobalt excess (as a cause of goiter) between goiterous and non goiterous children and to assay the relationship between serum cobalt and thyroid hormone...

Introduction: Adult Growth Hormone Deficiency (AGHD) is associated with osteoporosis. Underlying mechanisms involved in the pathogenesis include reduced target-organ sensitivity to the effect of PTH. Growth Hormone Replacement (GHR) in AGHD leads to increased PTH target-organ sensitivity and consequently increased bone turnover and bone mineral density (BMD).Aims: We determined the effect of alendronate, given in addition to GHR, on PTH target-organ sens...